Limited patches/plaques (covering <10% of the total skin surface)
Generalized patches/plaques (covering ≥10% of the total skin surface)
Clinically abnormal peripheral lymph nodes; dermatopathic lymphadenopathy or histopathological involvement by isolated atypical lymphocytes, without alteration of the lymph node architecture
Clinically abnormal peripheral lymph nodes; histopathological involvement by aggregates of atypical lymphocytes, without alteration of the lymph node architecture
IA
1
0
0,1
IB
2
IIA
1-2
IIB
3
0-2
IIIA
4
IIIB
IVA1
1-4
IVA2
IVB
0-3
Beyond the factors used to assign T, N, or M categories, no additional prognostic factors are required for stage grouping.2
The Lugano classification includes no prognostic variable for determination of stage. A separate TNM staging system is used for these lymphomas.
Definition: Extent involvement; solitary, regional, generalized (clinical)
Clinical significance: Therapy consideration, overall survival
Definition: Involvement of draining lymph node, nondraining or central (pathology)
Clinical significance: Overall survival
Definition: Visceral organ (pathology)
Definition: Histologic type, immunophenotype
Clinical significance: Affects choice of therapy and overall survival
The authors have not noted any emerging factors for clinical care.