Solitary skin involvement
Solitary lesion less than 5 cm
Solitary lesion greater than or equal to 5 cm
Regional skin involvement: multiple lesions limited to one body region or two contiguous body regions
All disease encompassing in a less than 15-cm circular area
All disease encompassing in a greater than or equal to 15-cm and less than 30-cm circular area
All disease encompassing in a greater than or equal to 30-cm circular area
Generalized skin involvement
Multiple lesions involving 2 noncontiguous body regions
Multiple lesions involving greater than or equal to 3 body regions
Regional lymph nodes cannot be assessed
No clinical or pathological lymph node involvement
Involvement of one peripheral node region that drains an area of current or prior skin involvement
Involvement of two or more peripheral node regions or involvement of any lymph node region that does not drain an area of current or prior skin involvement
Involvement of central nodes
There is no stage group for other primary cutaneous lymphomas – including cutaneous T-cell, B-cell, NK cell and non-MF/SS lymphoma – at this time.
Beyond the factors used to assign T, N, or M categories, no additional prognostic factors are required for stage grouping.2
The Lugano classification includes no prognostic variable for determination of stage. A separate TNM staging system is used for these lymphomas.
Definition: Extent involvement; solitary, regional, generalized (clinical)
Clinical significance: Therapy consideration, overall survival
Definition: Involvement of draining lymph node, nondraining or central (pathology)
Clinical significance: Overall survival
Definition: Visceral organ (pathology)
Definition: Histologic type, immunophenotype
Clinical significance: Affects choice of therapy and overall survival
The authors have not noted any emerging factors for clinical care.